Differential Expression of IFI16, IL-33 and CD55 Link Potential Common Pathogenic Mechanisms for COVID-19 and Ulcerative Colitis
This study reveals robust molecular commonalities between COVID-19 and UC, highlighting dysregulated immune pathways and regulatory networks as shared mechanisms. We propose novel drug-repurposing candidates supported by network-based evidence, offering potential therapeutic strategies for patients with comorbid COVID-19 and UC.
Authors
- Binghe Wang (ORCID: https://orcid.org/0000-0002-2200-5270)
- Yanbing Ding (ORCID: https://orcid.org/0000-0002-0689-2199)
- Jianan Ye (ORCID: https://orcid.org/0000-0002-6672-8040)
- Wenzhong Zhang (ORCID: https://orcid.org/0000-0001-9184-0723)
- Qing Di (ORCID: https://orcid.org/0000-0002-9680-8199)
- Yuanyuan Li (ORCID: https://orcid.org/0009-0001-4265-4008)
Institutions
- Nanjing Traditional Chinese Medicine Hospital (CN)
- Command Hospital Air Force (IN)
- Yangzhou University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Journal of Multidisciplinary Healthcare
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/jmdh.s543183
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jiangsu Commission of Health
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Yangzhou University
- Nanjing University