Exploring the bidirectional relationships between MRI resting-state functional connectivity networks and cardiovascular diseases: a Mendelian randomization study
Our findings reveal novel bidirectional causal relationships between specific brain functional networks and CVDs, with distinct patterns of network involvement for different CVDs suggesting disease-specific mechanisms in the cardio-cerebral axis. These findings identify potential neuroimaging biomarkers for early detection and monitoring of cardiovascular diseases.
Authors
- Ruiqin Han (ORCID: https://orcid.org/0000-0001-6811-7019)
- Shiqiang Yang (ORCID: https://orcid.org/0000-0001-5356-4094)
- Hanjian Du (ORCID: https://orcid.org/0000-0002-2353-8802)
- Qing Chun Gao (ORCID: https://orcid.org/0000-0001-8504-6128)
- Xiaofei Hu (ORCID: https://orcid.org/0000-0001-5376-2779)
- Qi Zhang (ORCID: https://orcid.org/0000-0002-4706-7662)
- Yuquan Wang (ORCID: https://orcid.org/0000-0003-3022-8738)
Institutions
- North Sichuan Medical University (CN)
- University of Electronic Science and Technology of China (CN)
- Army Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Affiliated Hospital of North Sichuan Medical College (CN)
- Southwest Hospital (CN)
- Chongqing Emergency Medical Center (CN)
- Second People’s Hospital of Yibin (CN)
- First People's Hospital of Chongqing (CN)
Publication Details
- Journal
- Brain Informatics
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1186/s40708-025-00285-8
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00