Changes in Frailty and Incident Cancer: Evidence From the Health and Retirement Study
Both baseline frailty and changes in frailty status are independently associated with cancer risk. Frailty progression significantly increases the risk of incident cancer, whereas recovery from frailty is associated with reduced risk. These findings underscore the importance of dynamic frailty monitoring and suggest that interventions targeting frailty warrant investigation for potential cancer risk reduction.
Authors
- Sanyu Ge (ORCID: https://orcid.org/0000-0001-6476-8682)
- Hong Zhao (ORCID: https://orcid.org/0000-0002-8069-9901)
- Hanping Shi (ORCID: https://orcid.org/0000-0003-4514-8693)
- Zhaoting Bu (ORCID: https://orcid.org/0000-0002-6289-1385)
- Xinying Chen (ORCID: https://orcid.org/0000-0002-5052-4991)
- Xin Zheng (ORCID: https://orcid.org/0000-0003-0915-7787)
- Xiangrui Li (ORCID: https://orcid.org/0000-0002-7143-6827)
- Yi Li (ORCID: https://orcid.org/0000-0003-0392-6661)
- Changhong Xu
- Bing Yin
- Xiaoyue Liu (ORCID: https://orcid.org/0000-0002-3742-8524)
Institutions
- Capital Medical University (CN)
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Beijing Shijitan Hospital (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/jcsm.70164
- Primary Topic
- Frailty in Older Adults
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Capital Medical University
- National Key Research and Development Program of China