Supporting efficacy and scaling with a next-generation T cell AOF formulation medium

Cell culture media are critical to successful cell therapy production, serving as a source of essential nutrients and maintaining the physiological conditions necessary for optimal cell growth and function. The use of well-defined, animal origin-free (AOF) media is increasingly recognized as being pivotal in ensuring experimental reproducibility, minimizing contamination risks, and addressing stringent regulatory requirements. This article explores the CTS™ OpTmizer™ One serum-free medium, an innovative AOF formulation tailored for T cell expansion. This medium is designed to enhance the early memory T cell phenotype, improve cell viability, and facilitate scalability, positioning it as a crucial tool for both preclinical research and clinical manufacturing.

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Publication Details

Journal
Cell and Gene Therapy Insights
Published
2024-10-01
DOI
https://doi.org/10.18609/cgti.2024.138
Primary Topic
Viral Infectious Diseases and Gene Expression in Insects
Type
article
Field-Weighted Citation Impact
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article

Supporting efficacy and scaling with a next-generation T cell AOF formulation medium

Arie Lang Gutowski, J. Kern
Cell and Gene Therapy Insights
Viral Infectious Diseases and Gene Expression in Insects
article

Supporting efficacy and scaling with a next-generation T cell AOF formulation medium

Arie Lang Gutowski, J. Kern
article en

Abstract

Cell culture media are critical to successful cell therapy production, serving as a source of essential nutrients and maintaining the physiological conditions necessary for optimal cell growth and function. The use of well-defined, animal origin-free (AOF) media is increasingly recognized as being pivotal in ensuring experimental reproducibility, minimizing contamination risks, and addressing stringent regulatory requirements. This article explores the CTS™ OpTmizer™ One serum-free medium, an innovative AOF formulation tailored for T cell expansion. This medium is designed to enhance the early memory T cell phenotype, improve cell viability, and facilitate scalability, positioning it as a crucial tool for both preclinical research and clinical manufacturing.

Cell and Gene Therapy InsightsVol. 10(9)
Thermo Fisher Scientific (United States) (US)
Openalex Percentile: Top 76%
Viral Infectious Diseases and Gene Expression in Insects
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