Optimizing bioprocess purification: effective nucleic acid removal in high salt environments

Efficient cell lysis and host cell DNA removal are crucial in biopharmaceutical purification, especially for viral vectors. This article will discuss how an advanced salt-active endonuclease can enhance bioprocess purification workflows by effectively removing nucleic acid impurities and meeting stringent regulatory standards.

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Publication Details

Journal
Cell and Gene Therapy Insights
Published
2024-10-30
DOI
https://doi.org/10.18609/cgti.2024.147
Primary Topic
Protein purification and stability
Type
article
Field-Weighted Citation Impact
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article

Optimizing bioprocess purification: effective nucleic acid removal in high salt environments

Eleonora Turco, Joanna Niska-Blakie
Cell and Gene Therapy Insights
Protein purification and stability
article

Optimizing bioprocess purification: effective nucleic acid removal in high salt environments

Eleonora Turco, Joanna Niska-Blakie
article en

Abstract

Efficient cell lysis and host cell DNA removal are crucial in biopharmaceutical purification, especially for viral vectors. This article will discuss how an advanced salt-active endonuclease can enhance bioprocess purification workflows by effectively removing nucleic acid impurities and meeting stringent regulatory standards.

Cell and Gene Therapy InsightsVol. 10(9)
University of Gdańsk (PL)
Openalex Percentile: Top 76%
Protein purification and stability
DOISourceOpenAlex
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Optimizing bioprocess purification: effective nucleic acid removal in high salt environments — Eleonora Turco, Joanna Niska-Blakie · Cell and Gene Therapy Insights (2024) | TGRS Research Map | TGRS