Comparative study between bovine bone with or without concentrated growth factor in treatment of chronic periodontitis

Abstract Introduction The goal of periodontal therapy is the regeneration of destructed periodontal tissues. There is a variable treatment modality for periodontal regenerative therapy. There was little information about the role of concentrated growth factors (CGF) combined with bovine bone and collagen membrane in improvement of angular bone loss. Aim The aim of this study was to compare bovine bone with or without concentrated growth factor in treatment of chronic periodontitis. Patients and method A total of 20 sites of intrabony defects were selected from patients who fulfill the inclusion criteria. The patients or sites in the same patient were randomly classified into two groups using closed envelopes. Group Ι: 10 sites were treated by CGF, collagen membrane and xenograft bone graft and group ΙΙ: 10 sites were treated by collagen membrane and xenograft bone graft. The following clinical parameters probing pocket depth, clinical attachment level, bleeding on probing, and plaque index all these parameters were measured at pretreatment, baseline and 6 months postsurgical treatment. The Radiographic parameters defect depth and bone density were measured at baseline and 6 months postsurgical by using cone beam computed tomography. Results Intergroup comparison for probing pocket depth and clinical attachment level showed a statistically significant ( P ≤ 0.005) in post 6 months in favor of group I. But the intergroup comparison for bleeding on probing and plaque index revealed no a statistically significant in all periods of evaluation. Moreover, Intergroup comparison for defect depth was a statistically significant ( P ≤ 0.005) at post 6 months in favor to group I. However, the intergroup comparison for bone density showed not statistically significant at baseline and post 6 months in the two groups. Conclusion Based on the results of the present study both treatment modalities resulted in clinical improvement as well as radiographic evidence of bone regeneration so these materials could be used successfully in the treatment of patients suffering from moderate to severe chronic periodontitis. Xenograft and collagen membrane showed relatively good results clinically and radiographically. However, the addition of CGF to bone graft gave better clinical and radiographical outcomes, therefore, using CGF is recommended for periodontal regeneration.