Mendelian Randomization Integrating GWAS and eQTL Data Reveals DAAM1, a Potential Immune-Related Biomarker for Breast Cancer Prognosis
This study identified DAAM1 as a key immune-related prognostic biomarker in breast cancer, whose upregulation contributes to tumor progression and metastasis via EMT pathway. Our findings, elaborated in a causal inference framework, provide a mechanistic basis for DAAM1's role in BC and underscore its potential as a therapeutic target.
Authors
- Yuanping Dai
- Jianqiao Cao (ORCID: https://orcid.org/0000-0003-4647-5717)
- Yizi Cong (ORCID: https://orcid.org/0000-0003-1349-6036)
- Guangdong Qiao (ORCID: https://orcid.org/0000-0002-5298-3411)
- Kun Zhang (ORCID: https://orcid.org/0009-0008-9929-7700)
- Gang Chen (ORCID: https://orcid.org/0000-0002-2514-4858)
- Zhe Zhang (ORCID: https://orcid.org/0000-0001-6021-6629)
- Ge Gao (ORCID: https://orcid.org/0000-0002-3474-8637)
- Yidan Wang (ORCID: https://orcid.org/0000-0001-7394-1571)
- Chao Yu (ORCID: https://orcid.org/0000-0001-8389-1512)
Institutions
- Yuhuangding Hospital (CN)
- Liuzhou Maternal and Child Health Hospital (CN)
Publication Details
- Journal
- Breast Cancer Targets and Therapy
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/bctt.s569177
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00