Antidepressant Effect of Short-Chain Fatty Acids on Chronic Unpredictable Mild Stress in Model Rats And Their Influence on the Oral-Gut Microbiota
SCFAs intervention ameliorated depression-like behaviors, modulated gut microbiota composition, enhanced ZO-1 expression, reduced gut inflammation, and promoted immune function, thereby restoring oral gut microbiota homeostasis. This study elucidated SCFAs' therapeutic potential of SCFAs in depression and provided a theoretical foundation for their clinical application in antidepressant treatments.
Authors
- Hongli Chen (ORCID: https://orcid.org/0000-0001-5580-707X)
- Jing Cao (ORCID: https://orcid.org/0000-0001-9551-5143)
- Zhiyuan Yang (ORCID: https://orcid.org/0000-0003-2013-2281)
- Yan Li (ORCID: https://orcid.org/0000-0002-6583-2751)
Institutions
- Shanxi Medical University (CN)
- Luliang University (CN)
- Shanxi Fenyang Hospital (CN)
Publication Details
- Journal
- Neuropsychiatric Disease and Treatment
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/ndt.s560434
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shanxi Medical University