Blood Stasis Constitution Ointment Exerts Anti-Lung Cancer Effects: A Study Integrating Network Pharmacology, Transcriptomics, and Experimental Validation
BSCO significantly inhibited lung cancer growth in vitro and in vivo. Network pharmacology and transcriptomics suggested that its anti-cancer effects might involve the PI3K-Akt signaling pathway, TP53, IL6, CDKN1A, and KIT may be its key targets.
Authors
- Q. Wang (ORCID: https://orcid.org/0009-0002-5446-3206)
- Tianming Lu (ORCID: https://orcid.org/0000-0003-3103-6973)
- Hu You
- Juhe Wang
- Qiuyan Guo (ORCID: https://orcid.org/0009-0007-8005-3995)
- Maobo Du (ORCID: https://orcid.org/0009-0003-6716-4755)
- Xingjiang Xiong (ORCID: https://orcid.org/0000-0002-6874-8344)
- Chuanhao Dai
- Shuo Shen
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Fourth People's Hospital of Sichuan Province (CN)
Publication Details
- Journal
- Cancer Management and Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/cmar.s563551
- Primary Topic
- Kruppel-like factors research
- Type
- article
- Field-Weighted Citation Impact
- 0.00