Long-Term Oncological Outcomes and Recurrence Patterns after Segmentectomy for Early-Stage Non-Small Cell Lung Cancer: A Dual-Centre Retrospective Study
Segmentectomy yields favourable long-term outcomes in selected early-stage NSCLC. Tumour size, grade, lymphovascular and pleural invasion, and lingular location are key predictors of recurrence, while neutrophil-to-lymphocyte ratio (NLR) may serve as a simple inflammatory biomarker of poorer prognosis. Incorporating functional and inflammatory biomarkers into preoperative assessment may help refine patient selection and postoperative surveillance strategies.
Authors
- Yolonda Lorig Colson (ORCID: https://orcid.org/0000-0002-8229-5636)
- Giuseppe Mangiameli (ORCID: https://orcid.org/0000-0002-8394-2719)
- Giuseppe Marulli (ORCID: https://orcid.org/0000-0001-6570-615X)
- Debora Brascia (ORCID: https://orcid.org/0000-0003-0860-1647)
- Matilde Luppichini
- Isha Mehta Warikoo
Institutions
- Humanitas University (IT)
- Harvard University (US)
- Massachusetts General Hospital (US)
- IRCCS Humanitas Research Hospital (IT)
Publication Details
- Journal
- European Journal of Cardio-Thoracic Surgery
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1093/ejcts/ezaf449
- Primary Topic
- Inflammatory Biomarkers in Disease Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00