hPMSC-derived Exosomal miR-26-5p modulates macrophage polarization for liver repair in DILI via PTEN/mTOR signaling
Based on our findings, it is suggested that the PTEN/mTOR/TGF-β1 signaling pathway is involved in regulating macrophage activation through hPMSC exosomal miR-26-5p, thereby highlighting its therapeutic potential in liver injury treatment.
Authors
- Lei Feng (ORCID: https://orcid.org/0000-0001-6053-8417)
- Mingxin Pan (ORCID: https://orcid.org/0000-0002-9133-3323)
- Shuyi Wei (ORCID: https://orcid.org/0000-0002-1427-4251)
- Yu Fu (ORCID: https://orcid.org/0000-0003-1244-9473)
- Shao Li (ORCID: https://orcid.org/0000-0002-8709-9167)
- Guolin He (ORCID: https://orcid.org/0000-0001-8032-1434)
- Zhi Zhang (ORCID: https://orcid.org/0000-0002-8148-0071)
- Ting Li (ORCID: https://orcid.org/0000-0001-6800-6650)
- Yang Li (ORCID: https://orcid.org/0000-0002-5882-2301)
- Liwei Liang (ORCID: https://orcid.org/0000-0003-4620-5792)
- Lei Cai (ORCID: https://orcid.org/0000-0003-1658-7996)
- Shunjun Fu (ORCID: https://orcid.org/0000-0001-5318-5908)
Institutions
- Guiyang Medical University (CN)
- Third Affiliated Hospital of Southern Medical University (CN)
- Third Affiliated Hospital of Guangzhou Medical University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- Zhujiang Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Cellular Signalling
- Published
- 2025-12-13
- DOI
- https://doi.org/10.1016/j.cellsig.2025.112272
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00