Data‐driven neuropsychological phenotypes in the Baltimore Longitudinal Study of Aging
Significant cognitive heterogeneity exists in CU older adults.LPA identified phenotypes based on cognitive performance.Personality and psychosocial characteristics differed by cognitive phenotype.Cognition over time and risk of cognitive impairment differed by cognitive phenotypes.The phenotype with greatest executive dysfunction had the fastest increase in NfL.
Authors
- Katherine J. Bangen (ORCID: https://orcid.org/0000-0002-1363-3179)
- Susan M. Resnick (ORCID: https://orcid.org/0000-0003-1115-7145)
- Emily C. Edmonds (ORCID: https://orcid.org/0000-0002-5130-0500)
- Alexandra J. Weigand (ORCID: https://orcid.org/0000-0002-7931-1383)
- Alden L. Gross (ORCID: https://orcid.org/0000-0002-4678-0562)
- Caitlin M. Terao (ORCID: https://orcid.org/0000-0002-5506-9625)
- Fareshte R. Erani (ORCID: https://orcid.org/0000-0001-6517-7980)
- Keenan A. Walker (ORCID: https://orcid.org/0000-0002-5989-9853)
- Kelsey R. Thomas (ORCID: https://orcid.org/0000-0003-4277-8876)
- Yang An
Institutions
- Alzheimer's Association (US)
- University of Arizona (US)
- Johns Hopkins University (US)
- University of California, San Francisco (US)
- San Diego State University (US)
- University of California San Diego (US)
- VA San Diego Healthcare System (US)
- University Memory and Aging Center (US)
- National Institute on Aging (US)
- Banner Alzheimer’s Institute
Publication Details
- Journal
- Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/dad2.70220
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Alzheimer's Association
- National Institutes of Health
- National Institute on Aging