Fetal heart and surroundings: umbilical cord traction triggers sympathetic heart rate surge in fetal lambs in the artificial womb
Umbilical cord traction appears to activate an umbilico-neuro-cardiac reflex through sympathetic ANS pathways in ANS-mature fetuses. This mechanism may underlie clinical CTG features such as the double mountain peak sign and fetal tachycardia outside of labor.
Authors
- Alan W. Flake (ORCID: https://orcid.org/0000-0003-4913-7588)
- Salvatore Giovanni Castaldi (ORCID: https://orcid.org/0009-0007-2546-0280)
- Aaron Weilerstein
- Marilyn Heffelfinger
- Grace Hwang (ORCID: https://orcid.org/0000-0001-7730-6516)
- Maria Antonietta Castaldi (ORCID: https://orcid.org/0000-0001-9004-1022)
- Marcus G. Davey
- Maria Silena Mosquera
Institutions
- University of Salerno (IT)
- Westchester Medical Center (US)
- Children's Hospital of Philadelphia (US)
- Philadelphia University (US)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-11-04
- DOI
- https://doi.org/10.3389/fmed.2025.1667607
- Primary Topic
- Neonatal and fetal brain pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Children's Hospital of Philadelphia
- Università degli Studi di Salerno