Repurposing fusidic acid through colistin-mediated membrane permeabilization against <i>Escherichia coli</i> co-harboring <i>mcr</i> -1 and <i>bla</i> NDM-5
CST markedly enhances FA activity against mcr-1-positive E. coli by compromising outer membrane integrity and facilitating intracellular antibiotic accumulation. This synergy highlights a rational combination approach to restore the efficacy of obsolete antibiotics for multidrug-resistant Gram-negative bacteria.
Authors
- Meng-Ting Tao (ORCID: https://orcid.org/0009-0005-9512-8481)
- Yu‐Feng Zhou (ORCID: https://orcid.org/0000-0001-6882-5058)
- Ting-Yin Lu
- Wenhui Su (ORCID: https://orcid.org/0009-0003-7635-6265)
Institutions
- South China Agricultural University (CN)
- Jinan University (CN)
- Animal Science Research Institute (CN)
Publication Details
- Journal
- Journal of Applied Microbiology
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1093/jambio/lxaf305
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00