Oral Prescription Containing Ceramide, Proanthocyanidins, Quercetin, and Citrus Flavonoids Improves Sensitive Skin in Mice by Modulating Inflammation, Skin Barrier Function, and Gut Microbiota
The oral formulation containing ceramides, proanthocyanidins, quercetin, and citrus flavonoids improves skin barrier function, reduces inflammation, restores skin hydration, and modulates the skin-gut axis through multi-pathway and multi-target mechanisms, effectively alleviating symptoms of atopic dermatitis and dry skin, thus highlighting its potential as a novel dietary supplement for treating sensitive skin and related conditions.
Authors
- Xiaohui Yang (ORCID: https://orcid.org/0000-0002-5453-2702)
- Yaqi Yang (ORCID: https://orcid.org/0000-0001-7104-0219)
- Shanpeng Chu
- Ping Han
- Chaoyue Wang (ORCID: https://orcid.org/0000-0002-3149-5718)
- Ling Jiang (ORCID: https://orcid.org/0009-0008-8469-1473)
- Guangling Yin
- Jieqiong Chen (ORCID: https://orcid.org/0000-0003-1673-6517)
- Miaohong Yang (ORCID: https://orcid.org/0009-0001-3349-1542)
- Lingna Xie
- Zhiyun Du (ORCID: https://orcid.org/0000-0003-3793-8601)
Institutions
- Guangdong University of Technology (CN)
- Guangdong Pharmaceutical University (CN)
- Guangzhou Institute of Dermatology (CN)
- Department of Health of Guangdong Province (CN)
Publication Details
- Journal
- Journal of Cosmetic Dermatology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1111/jocd.70468
- Citations
- 1
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.00