Combined clinical, metabolomic, and polygenic scores for cardiovascular risk prediction
Combining NMR metabolomic, polygenic, and clinical biomarkers with SCORE2 enhanced prediction of first-onset CVD and could have substantial population health benefit if applied at scale.
Authors
- Savita Karthikeyan (ORCID: https://orcid.org/0000-0002-4798-5746)
- Angela Wood (ORCID: https://orcid.org/0000-0002-7937-304X)
- C. Coffey (ORCID: https://orcid.org/0000-0001-6915-1139)
- Emanuele Di Angelantonio (ORCID: https://orcid.org/0000-0001-8776-6719)
- Xilin Jiang (ORCID: https://orcid.org/0000-0001-6773-9182)
- Yang Liu (ORCID: https://orcid.org/0000-0002-5694-8760)
- Joel T. Gibson (ORCID: https://orcid.org/0000-0002-8967-4188)
- Samuel A. Lambert (ORCID: https://orcid.org/0000-0001-8222-008X)
- Scott C. Ritchie (ORCID: https://orcid.org/0000-0002-8454-9548)
- Lisa Pennells (ORCID: https://orcid.org/0000-0002-8594-3061)
- Michael Inouye (ORCID: https://orcid.org/0000-0001-9413-6520)
- Yu Xu (ORCID: https://orcid.org/0000-0002-7304-5045)
- Stephen Kaptoge (ORCID: https://orcid.org/0000-0002-1155-4872)
- Adam S. Butterworth (ORCID: https://orcid.org/0000-0002-6915-9015)
- Praveen Surendran (ORCID: https://orcid.org/0000-0002-4911-6077)
- John Danesh
Institutions
- Harvard University (US)
- Baker Heart and Diabetes Institute (AU)
- University of Cambridge (GB)
- Royal Papworth Hospital (GB)
- Wellcome Sanger Institute (GB)
- British Heart Foundation (GB)
- National Institute for Health and Care Research (GB)
- Human Technopole (IT)
Publication Details
- Journal
- European Heart Journal
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1093/eurheartj/ehaf947
- Citations
- 4
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.22