Extracellular Vesicles Derived from Human Embryonic Stem CellsReduce The Stemness Properties of Cancer Cell Lines.
These findings suggest that hESC-EVs transmit powerful regulatory signals capable of inducing the loss of stem cell characteristics in aggressive cancer cells. This mechanism offers a potential pathway for reprogramming highly malignant tumor cells toward a more differentiated and less aggressive phenotype, suggesting a novel strategy for anti-cancer therapy.
Authors
- Maryam Saber (ORCID: https://orcid.org/0000-0001-9309-7363)
- Seyedeh‐Nafiseh Hassani (ORCID: https://orcid.org/0000-0001-5047-8406)
- Reza Azmakan
- Mehran Rezaei Larijani (ORCID: https://orcid.org/0009-0002-0340-1267)
- Maryam Akhoundi
- Atefeh Safarpour
- Marzieh Ebrahimi (ORCID: https://orcid.org/0000-0003-1140-0379)
- Niloofar Sodeifi
Institutions
- University of Science and Culture (IR)
- Royan Institute (IR)
- Academic Center for Education, Culture and Research (IR)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- PubMed
- Published
- 2025-12-09
- DOI
- https://doi.org/10.22074/cellj.2025.2049975.1768
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00