Comparison of Epidemiological Estimates for 19 Cancer Types Using Electronic Health Record Databases in England: An Analysis of CPRD Aurum and CPRD GOLD Databases with Linked Hospital Episode Statistics and Cancer Registry Data

Findings highlight variation in cancer recording across different data sources. Researchers using CPRD data should assess the benefit of incorporating linked data on a study-by-study basis. For studies of breast, prostate, and lung cancers, CPRD Aurum or GOLD alone may be sufficient; however, linkage to HES and/or CR is recommended where a more complete case capture is required.