LAMC2 promotes gallbladder carcinoma metastasis through the TGF-β pathway
Our findings suggest that LAMC2 promotes GBC progression and metastasis, potentially by regulating the TGF-β signaling pathway. Therefore, LAMC2 could serve as a potential prognostic biomarker and therapeutic target for GBC.
Authors
- Erdong Liu
- Xiaofan Feng (ORCID: https://orcid.org/0000-0001-7177-6728)
- Liwei Dong (ORCID: https://orcid.org/0000-0003-2116-1674)
- Tianyi Jiang (ORCID: https://orcid.org/0000-0002-0515-4434)
- Yanan Zhou (ORCID: https://orcid.org/0000-0002-5150-2591)
- Yun‐Kai Lin (ORCID: https://orcid.org/0009-0006-3343-0017)
- Mengyou Xu (ORCID: https://orcid.org/0000-0003-3919-6082)
- Taiyu Shang
- Yuanyuan Zhang (ORCID: https://orcid.org/0000-0002-0329-2518)
- Hongyang Wang (ORCID: https://orcid.org/0000-0002-6197-6133)
- Yufei Pan (ORCID: https://orcid.org/0000-0002-7658-9064)
- Hailan Feng (ORCID: https://orcid.org/0000-0002-7640-5990)
- Yibin Chen (ORCID: https://orcid.org/0009-0004-0423-5218)
Institutions
- Center for Naval Analyses (US)
- Second Military Medical University (CN)
- Peking University (CN)
- Fudan University (CN)
- Fudan University Shanghai Cancer Center (CN)
- Peking University Cancer Hospital (CN)
- Shanghai Cancer Institute (CN)
- 181st Hospital of Chinese People's Liberation Army (CN)
- Eastern Hepatobiliary Surgery Hospital (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-12-14
- DOI
- https://doi.org/10.1186/s12935-025-04123-z
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00