The Blood–Brain Barrier as an Integration Hub in Alzheimer's Disease: How Microbiota Metabolites Modulate Central Signal Processing

Viewing the BBB as an active integration interface offers a useful perspective for organizing current evidence on gut-brain interactions in AD. This conceptual perspective suggests that therapeutic strategies might benefit from supporting BBB integration capacity and optimizing metabolite-processing mechanisms alongside improving gut health.

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Publication Details

Journal
CNS Neuroscience & Therapeutics
Published
2025-12-01
DOI
https://doi.org/10.1002/cns.70703
Primary Topic
Gut microbiota and health
Type
article
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article

The Blood–Brain Barrier as an Integration Hub in Alzheimer's Disease: How Microbiota Metabolites Modulate Central Signal Processing

Rita Maccarone, O Giangiulio
CNS Neuroscience & Therapeutics
Gut microbiota and health
article

The Blood–Brain Barrier as an Integration Hub in Alzheimer's Disease: How Microbiota Metabolites Modulate Central Signal Processing

Rita Maccarone, O Giangiulio
article en

Abstract

Viewing the BBB as an active integration interface offers a useful perspective for organizing current evidence on gut-brain interactions in AD. This conceptual perspective suggests that therapeutic strategies might benefit from supporting BBB integration capacity and optimizing metabolite-processing mechanisms alongside improving gut health.

CNS Neuroscience & TherapeuticsVol. 31(12)
University of L'Aquila (IT)
Openalex Percentile: Top 63%
Gut microbiota and health
DOIOpen Access PDFOpenAlex
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The Blood–Brain Barrier as an Integration Hub in Alzheimer's Disease: How Microbiota Metabolites Modulate Central Signal Processing — Rita Maccarone, O Giangiulio · CNS Neuroscience & Therapeutics (2025) | TGRS Research Map | TGRS