Functionalized nanopipettes for pH-gated single cell DNA delivery
Here, we present i-motif-functionalized glass nanopipettes that enable pH-triggered DNA release into single living cells. Acid-induced folding of the i-motif drives complementary strand dissociation through the ∼80 nm tip with minimal invasiveness. This pH-gated nanopipette enables reversible, on-demand single cell DNA delivery <i>via</i> rectification changes, establishing a potential platform for intracellular manipulation.
Authors
- Shiyu Zheng
- Ruo‐Can Qian (ORCID: https://orcid.org/0000-0002-1039-9866)
- Mengqi Zhao (ORCID: https://orcid.org/0000-0003-1640-4176)
- Xinyue Liu (ORCID: https://orcid.org/0000-0002-0934-4155)
- Jian Lv (ORCID: https://orcid.org/0000-0001-7633-366X)
- Man‐Sha Wu
- Dawei Li (ORCID: https://orcid.org/0000-0002-6001-7379)
- Binbin Chen (ORCID: https://orcid.org/0000-0001-7533-0686)
- Shiyi Zhang (ORCID: https://orcid.org/0009-0008-8983-0997)
Institutions
- East China University of Science and Technology (CN)
- Shanghai Institute of Technology (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1039/d5cc05685c
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00