Development of Simple Fluorescence Spectrometry With Blue Emissive V ₂ C MXene for Selective Detection of Rabeprazole Sodium in Pharmaceutical Samples

Etching is a well-established method to create particles with nano-level precision. Herein, we have synthesized vanadium carbide (V₂C) MXene fluorescent nanoparticles (FNPs) for the determination of rabeprazole sodium (R-Na) in drug samples. The prepared V₂C MXene FNPs show blue emission under 365 nm of UV light with a good quantum yield of 9.70%. The synthesized V₂C MXene FNPs showed the highest fluorescent intensity up on excitation at 350 nm, giving a maximum emission wavelength of 428 nm. Fascinatingly, the fluorescence intensity of V₂C MXene FNPs shows remarkable quenching upon the addition of R-Na over a range of 0.1-5 μM with a detection limit of 0.09 μM. The designed V₂C MXene FNP-based probe was successfully applied to the assay of R-Na in its pharmaceutical samples and biofluids. This work is also assessed in terms of its greenness and blueness using metrics like the Complex Green Analytical Procedure Index (GAPI) and the Blue Applicability Grade Index (BAGI) tools. Bringing together, V₂C MXene FNPs could be admitted as a promising fluorescent probe for assaying R-Na in drug samples with justifiable accuracy and precision.