Detrimental Effect of Early Clazosentan Administration on Neurogenic Pulmonary Edema Following Subarachnoid Hemorrhage and Safety of Its Delayed Administration: Laboratory Investigation
While the early administration of clazosentan exacerbated SAH-induced NPE, delayed administration did not exhibit this detrimental effect. Clazosentan may safely be utilized in clinical settings for patients with SAH who develop NPE, provided that NPE shows improvement.
Authors
- Yukiko Enomoto (ORCID: https://orcid.org/0000-0003-0019-7029)
- Yoshiki Kuse (ORCID: https://orcid.org/0000-0001-8484-7265)
- Yusuke Egashira (ORCID: https://orcid.org/0000-0002-8143-3531)
- Masamitsu Shimazawa (ORCID: https://orcid.org/0000-0001-9141-8733)
- Toru Iwama (ORCID: https://orcid.org/0000-0002-9426-284X)
- Hideaki Hara (ORCID: https://orcid.org/0000-0003-2046-9001)
- Tsuyoshi Izumo (ORCID: https://orcid.org/0000-0001-8778-2698)
- Shinsuke Nakamura
- Shinomi Sasaibe
- Nozomi Sasaki (ORCID: https://orcid.org/0000-0002-7957-3690)
- Masaki Kumagai
- Hirofumi Matsubara
Institutions
- Gifu Pharmaceutical University (JP)
- Gifu Municipal Hospital (JP)
- Takayama Red Cross Hospital (JP)
- Gifu University (JP)
Publication Details
- Journal
- World Neurosurgery
- Published
- 2025-12-13
- DOI
- https://doi.org/10.1016/j.wneu.2025.124721
- Primary Topic
- Takotsubo Cardiomyopathy and Associated Phenomena
- Type
- article
- Field-Weighted Citation Impact
- 0.00