Histone lactylation‐mediated up‐regulation of IGF2BP2 enhances ferroptosis resistance via Nrf2 in colorectal cancer
Lactate drives H3K18la-mediated transcriptional activation of IGF2BP2 in CRC. IGF2BP2 protein stabilises Nrf2 mRNA by binding to its m<sup>6</sup>A modification site. The lactate-IGF2BP2-Nrf2 axis confers ferroptosis resistance in CRC cells. This pathway simultaneously promotes M2 macrophage polarisation in the tumour microenvironment.
Authors
- Jing Song (ORCID: https://orcid.org/0000-0001-7427-8177)
- Dongsheng Guo (ORCID: https://orcid.org/0000-0001-8007-8729)
- Jin‐Feng Zhu
- Hailin Lv (ORCID: https://orcid.org/0000-0001-6667-5463)
- Zhipin Liang (ORCID: https://orcid.org/0000-0001-9404-9339)
- Wei Zeng (ORCID: https://orcid.org/0009-0007-2337-3255)
Institutions
- Sun Yat-sen University (CN)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/ctm2.70551
- Citations
- 2
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 3.04