Cholesterol-metabolic tumor-associated macrophages regulate tumor budding-like cell subpopulation to promote chordoma stemness via BACH1/ANGPTL4/SDC4 axis
BACH1-driven CM-TAMs activate TBLCs via the ANGPTL4-SDC4 signaling axis, promoting stemness and cholesterol accumulation, ultimately driving malignant progression in chordoma. These findings uncover a previously unrecognized tumor-immune-metabolic interaction and suggest potential therapeutic targets for this disease.
Authors
- Sheng‐Kai Liang (ORCID: https://orcid.org/0000-0003-3486-2293)
- Tao‐Lan Zhang (ORCID: https://orcid.org/0000-0002-0049-128X)
- Pengfei Wu (ORCID: https://orcid.org/0000-0002-8660-3464)
- Bo‐Wen Zheng (ORCID: https://orcid.org/0000-0002-9308-3794)
- Hua-Qing Niu
- Makoto Endo (ORCID: https://orcid.org/0000-0002-7956-2190)
- Ming-Xiang Zou (ORCID: https://orcid.org/0000-0003-2005-8472)
- Chao Xia (ORCID: https://orcid.org/0000-0002-2787-1493)
- Lingxiang Jiang (ORCID: https://orcid.org/0000-0003-1794-0755)
- Bo‐Yv Zheng
- Jing Li (ORCID: https://orcid.org/0009-0007-1333-7752)
- Wei Huang (ORCID: https://orcid.org/0000-0003-1216-5884)
- Bin Luo (ORCID: https://orcid.org/0000-0001-9485-4186)
Institutions
- Indiana University Health (US)
- Kyushu University (JP)
- Central South University (CN)
- Peking University (CN)
- Guangzhou Women and Children Medical Center (CN)
- Indiana Cancer Consortium (US)
- Second Affiliated Hospital of Zhengzhou University (CN)
- Peking University People's Hospital (CN)
- Wuhan Union Hospital (CN)
- First Affiliated Hospital of University of South China (CN)
- Central Hospital of Wuhan (CN)
- Chenzhou First People's Hospital (CN)
- Wuhan General Hospital of Guangzhou (CN)
- Hengyang Academy of Agricultural Sciences (CN)
- Second Xiangya Hospital of Central South University (CN)
- Indiana University – Purdue University Indianapolis (US)
- University of South China (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-12-11
- DOI
- https://doi.org/10.1093/neuonc/noaf286
- Citations
- 1
- Primary Topic
- Lipid metabolism and disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.39