Long‐term changes in cardiorespiratory fitness and incidence of Alzheimer's disease and related dementias among US Veterans
Poor cardiorespiratory fitness (CRF) has been identified as a potential risk factor for Alzheimer's disease and related dementias (ADRD). Thus, we assessed the potential impact of changes in CRF over time on ADRD risk.CRF changes reflected inverse and proportional changes in ADRD risk.Low-fit individuals who improved their CRF by ≥0.1 metabolic equivalents (METs) had a 13%-24% lower ADRD risk. Conversely, a decline in CRF by ≥2.0 METs was associated with a 14% increased ADRD risk among Moderate-fit and a 18% increase among High-fit individuals.
Authors
- Brandon L. Alderman (ORCID: https://orcid.org/0000-0003-0101-6533)
- Xuemei Sui (ORCID: https://orcid.org/0000-0003-2368-7311)
- Charles Faselis (ORCID: https://orcid.org/0000-0001-9895-0327)
- Peter Kokkinos (ORCID: https://orcid.org/0000-0001-6055-7634)
- Yan Cheng (ORCID: https://orcid.org/0000-0001-7189-3991)
- Qing Zeng‐Treitler (ORCID: https://orcid.org/0000-0002-8353-7473)
- Jonathan A. Myers (ORCID: https://orcid.org/0000-0003-1670-7126)
- Charity Johanna Morgan (ORCID: https://orcid.org/0000-0003-0693-4739)
- Edward Zamrini (ORCID: https://orcid.org/0000-0002-3685-4580)
- Barry A. Franklin (ORCID: https://orcid.org/0009-0006-7909-0425)
- Helen Sheriff
Institutions
- Rutgers, The State University of New Jersey (US)
- University of South Carolina (US)
- George Washington University (US)
- University of California, Irvine (US)
- VA Palo Alto Health Care System (US)
- University of Alabama at Birmingham (US)
- Washington DC VA Medical Center (US)
- Beaumont Hospital, Troy (US)
- Stanford University (US)
Publication Details
- Journal
- Alzheimer s & Dementia Translational Research & Clinical Interventions
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/trc2.70171
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Veterans Affairs
- Office of Research and Development
- Health Services Research and Development
- National Institutes of Health