Cerebral metabolic covariance in delirium: pattern response to symptomatic changes
Derivation of a DP, primarily attributable to delirium itself, rather than acute illness or dementia. The DP revealed metabolic dysfunction spanning large-scale networks, consistent with the proposed model of delirium as global brain failure. DP expression was elevated in delirium, both with and without dementia, compared to healthy and acutely unwell controls. In participants with follow-up, clinical recovery was paralleled by a reduction in DP expression. The delirium pattern reflected clinically responsive and modifiable network dysfunction.
Authors
- Sarah Joanna Richardson (ORCID: https://orcid.org/0000-0002-5771-1845)
- Anita Nitchingham (ORCID: https://orcid.org/0000-0002-9215-0844)
- Gideon A. Caplan (ORCID: https://orcid.org/0000-0002-9991-3146)
- Sean J. Colloby
- Rachael A. Lawson (ORCID: https://orcid.org/0000-0003-2608-8285)
- John T. O’Brien (ORCID: https://orcid.org/0000-0002-0837-5080)
- Robert Welschinger
- John‐Paul Taylor (ORCID: https://orcid.org/0000-0001-7958-6558)
- Eva A. Wegner (ORCID: https://orcid.org/0000-0002-4434-7183)
Institutions
- University of Cambridge (GB)
- UNSW Sydney (AU)
- Prince of Wales Hospital (AU)
- Neuroscience Research Australia (AU)
- Newcastle University (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz.70993
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00