Systemic Piezo1 activation improves cerebrovascular function in Alzheimer's disease
An Alzheimer's disease (AD) animal model demonstrates reduced brain capillary blood flow and impaired neurovascular coupling. Pharmacological activation of Piezo1 at the systemic level improves blood flow and functional hyperemia during AD. Piezo1 is involved in cerebrovascular dysfunction associated with AD.
Authors
- Xin Rui Lim (ORCID: https://orcid.org/0000-0002-4166-0377)
- Supriya Chakraborty (ORCID: https://orcid.org/0000-0001-9301-2649)
- Zeynab Tabrizi
- Oliver Bracko (ORCID: https://orcid.org/0000-0002-9414-6590)
- Osama F. Harraz (ORCID: https://orcid.org/0000-0003-2061-1100)
Institutions
- University of Vermont (US)
- University of Miami (US)
- Vermont Department of Health (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz.71016
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Silicon Valley Community Foundation
- Alzheimer's Association
- American Heart Association
- University of Miami
- Florida Department of Health
- National Heart, Lung, and Blood Institute
- National Institute of General Medical Sciences
- Cardiovascular Research Institute of Vermont, Larner College of Medicine, University of Vermont