Epigenetic clocks and longitudinal plasma biomarkers of Alzheimer's disease
We studied 2366 older women from the Women's Health Initiative Memory Study. AgeAccelHorvath and AgeAccelPheno were linked to lower plasma Aβ42:Aβ40 at baseline. AgeAccelGrim2, PCPhenoAge, and PCGrimAge were linked to higher plasma NfL at baseline. DunedinPACE was associated with faster increases in p-tau181, p-tau217, NfL, and GFAP.
Authors
- Steve Horvath (ORCID: https://orcid.org/0000-0002-4110-3589)
- Aladdin H. Shadyab (ORCID: https://orcid.org/0000-0002-9693-0522)
- Adam X. Maihofer (ORCID: https://orcid.org/0000-0003-4517-1623)
- Linda K. McEvoy (ORCID: https://orcid.org/0000-0003-4583-7798)
- JoAnn E. Manson (ORCID: https://orcid.org/0000-0002-9426-7595)
- Kenneth B. Beckman (ORCID: https://orcid.org/0000-0001-8876-0706)
- Brian Silver (ORCID: https://orcid.org/0000-0002-1562-9894)
- Steve Nguyen (ORCID: https://orcid.org/0000-0002-5193-7042)
- Stephen R. Rapp (ORCID: https://orcid.org/0000-0002-9766-3104)
- Mark A. Espeland (ORCID: https://orcid.org/0000-0002-3711-1949)
- Bowei Zhang (ORCID: https://orcid.org/0009-0000-9686-0897)
- Michelle M. Mielke (ORCID: https://orcid.org/0000-0001-7177-1185)
- Danni Li (ORCID: https://orcid.org/0000-0002-0608-2831)
- Caroline M. Nievergelt
- Andrea Z LaCroix
- Ake T Lu
- Susan M. Resnick
- Luigi Ferrucci
Institutions
- Brigham and Women's Hospital (US)
- National Institutes of Health (US)
- University of Minnesota (US)
- Harvard University (US)
- Kaiser Permanente Washington Health Research Institute (US)
- University of Massachusetts Chan Medical School (US)
- University of Minnesota System (US)
- University of California San Diego (US)
- Human Longevity (United States) (US)
- National Institute on Aging (US)
- Wake Forest University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz.70983
- Citations
- 2
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- National Heart, Lung, and Blood Institute