Burden and trends of NASH-related liver cancer associated with high fasting plasma glucose in China and globally from 1990 to 2021: a population-based analysis of the global burden of disease study

From 1990 to 2021, the burden of NASH-related liver cancer associated with HFPG increased substantially in both global and Chinese populations. High-risk groups, including men, older individuals, those with elevated fasting plasma glucose and patients with NASH, should be closely monitored. Targeted screening and preventive strategies for these populations may help manage the disease burden. Future studies are needed to determine whether effective blood glucose control can reduce the risk of NASH-related liver cancer.

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Publication Details

Journal
BMJ Open
Published
2025-12-01
DOI
https://doi.org/10.1136/bmjopen-2025-102345
Primary Topic
Liver Disease Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00

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article

Burden and trends of NASH-related liver cancer associated with high fasting plasma glucose in China and globally from 1990 to 2021: a population-based analysis of the global burden of disease study

Youjian Yao, Cheng-Ye Ji, Mei Gui, Chenchen Zhou
BMJ Open
Liver Disease Diagnosis and Treatment
article

Burden and trends of NASH-related liver cancer associated with high fasting plasma glucose in China and globally from 1990 to 2021: a population-based analysis of the global burden of disease study

Youjian Yao, Cheng-Ye Ji, Mei Gui, Chenchen Zhou
article en

Abstract

From 1990 to 2021, the burden of NASH-related liver cancer associated with HFPG increased substantially in both global and Chinese populations. High-risk groups, including men, older individuals, those with elevated fasting plasma glucose and patients with NASH, should be closely monitored. Targeted screening and preventive strategies for these populations may help manage the disease burden. Future studies are needed to determine whether effective blood glucose control can reduce the risk of NASH-related liver cancer.

BMJ OpenVol. 15(12)
Huazhong University of Science and Technology (CN), Hainan Medical University (CN)
Hainan Medical University, Jilin Office of Philosophy and Social Science
Openalex Percentile: Top 48%
Liver Disease Diagnosis and Treatment
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