Identifying long-term healthcare and sociodemographic risk factors for lower extremity amputation: a 10-year national registry-based case–control study in Denmark
This study identifies characteristics associated with LEA, including long-term exposure to dicloxacillin and opioid analgesics, alongside polypharmacy and socioeconomic disadvantage. These factors were detectable up to 10 years before amputation and may serve as early indicators for risk identification and guide targeted general practitioner interventions.
Authors
- Helle Gybel Juul‐Larsen (ORCID: https://orcid.org/0000-0002-8543-9201)
- Thomas Kallemose (ORCID: https://orcid.org/0000-0002-7356-6481)
- Klaus Kirketerp‐Møller (ORCID: https://orcid.org/0000-0002-3248-8448)
- Pia Søe Jensen (ORCID: https://orcid.org/0000-0002-0116-722X)
Institutions
- Roskilde University (DK)
- Bispebjerg Hospital (DK)
- Hvidovre Hospital (DK)
- Copenhagen University Hospital (DK)
Publication Details
- Journal
- BMJ Open
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1136/bmjopen-2025-112203
- Citations
- 1
- Primary Topic
- Diabetic Foot Ulcer Assessment and Management
- Type
- article
- Field-Weighted Citation Impact
- 1.29
Funders
- Novo Nordisk
- Hvidovre Hospital
- Novo Nordisk Fonden