FOXP3+ T Cells—An Emerging Evidence in Periodontitis Therapeutics
Understanding the mechanisms governing FOXP3+ Treg stability and their interaction with pathogenic Th17 responses is essential for developing targeted immunomodulatory therapies. Future research should focus not only on selectively expanding Tregs but also on translational strategies such as adoptive Treg transfer and IL-17 inhibition, while carefully balancing efficacy and the risk of systemic immunosuppression.
Authors
- Yinli Liu (ORCID: https://orcid.org/0000-0001-7606-8229)
- Tamer Badawy (ORCID: https://orcid.org/0000-0002-6292-9216)
- Revan Birke Koca Ünsal (ORCID: https://orcid.org/0000-0003-1540-983X)
- Carel Brigi (ORCID: https://orcid.org/0000-0003-1396-1137)
- Akira Hasuike (ORCID: https://orcid.org/0000-0001-5150-2076)
- Bruno Špiljak (ORCID: https://orcid.org/0000-0003-2545-4474)
- Akhilanand Chaurasia (ORCID: https://orcid.org/0000-0002-8356-9512)
- Monal Yuwanati (ORCID: https://orcid.org/0000-0001-9233-8292)
- Farah Asa’ad (ORCID: https://orcid.org/0000-0001-5186-2645)
- Danilo Milanés Zambrano (ORCID: https://orcid.org/0000-0003-1261-1776)
- Jelena Roganović (ORCID: https://orcid.org/0000-0002-2950-4056)
Institutions
- Nihon University (JP)
- Western University (CA)
- Cairo University (EG)
- University of Zagreb (HR)
- King George's Medical University (IN)
- Academic Center for Dentistry Amsterdam (NL)
- University of Sharjah (AE)
- University of Kigali (RW)
- University of Belgrade (RS)
- University of Rwanda (RW)
- Rwanda Biomedical Center (RW)
- Andalas University (ID)
- Saveetha University (IN)
- University of Gothenburg (SE)
Publication Details
- Journal
- Clinical and Experimental Dental Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/cre2.70263
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 0.00