Tertiary lymphoid structure‐related RNA indicator as metastasis risk factor in nasopharyngeal carcinoma
In this multicentre study, we established a new and robust predictive model for NPC distant metastasis using markers selected by a Pareto optimisation approach designed for multi-cohort data. When combined with clinical parameters, our RNA-based risk score significantly improved the area under the curve to 90.4%. This study revealed that reduced B-cell immunity, and TLS formation, may be associated with NPC metastasis, providing insights for the future studies in NPC metastasis.
Authors
- Man‐Kyo Chung (ORCID: https://orcid.org/0000-0001-7637-1148)
- Anne W.M. Lee (ORCID: https://orcid.org/0000-0003-2972-0231)
- Zhaozheng Hou (ORCID: https://orcid.org/0000-0001-8548-2798)
- Wai Tong Ng (ORCID: https://orcid.org/0000-0001-6696-3000)
- Ngar‐Woon Kam (ORCID: https://orcid.org/0000-0002-4053-6040)
- Chi‐Leung Chiang (ORCID: https://orcid.org/0000-0002-9836-6478)
- Kazi Anisha Islam (ORCID: https://orcid.org/0000-0001-5457-0648)
- Jason W.H. Wong (ORCID: https://orcid.org/0000-0003-2953-7728)
- Yingpei Zhang
- Ping Feng (ORCID: https://orcid.org/0000-0002-2736-8345)
- Wei Dai (ORCID: https://orcid.org/0000-0002-5558-0685)
- Ying Wang (ORCID: https://orcid.org/0000-0002-5554-6292)
- Victor Lee (ORCID: https://orcid.org/0000-0002-6283-978X)
- Songran Liu (ORCID: https://orcid.org/0000-0001-8770-7962)
- Zilu Huang
- Yunfei Xia
- Dora Lai‐Wan Kwong (ORCID: https://orcid.org/0000-0002-1304-2854)
Institutions
- Sun Yat-sen University (CN)
- State Key Laboratory of Synthetic Chemistry (CN)
- University of Hong Kong - Shenzhen Hospital (CN)
- Sun Yat-sen University Cancer Center (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/ctm2.70539
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Science and Technology Planning Project of Guangdong Province