Divergent evolution of hepatocellular carcinoma genomes in chimpanzees and humans
Chimpanzee HCCs are defined by high mutational burden and frequent <b><i>TSC2</i></b> alterations, contrasting with the more selectively constrained mutation spectrum of human HCC. Divergent evolutionary patterns highlight species-specific oncogenic routes while underscoring conserved pathways. Comparative primate cancer genomics offers novel insights into cancer evolution, biomarkers, and therapeutic targets.
Authors
- Katarzyna Michalak‐Micka (ORCID: https://orcid.org/0009-0002-1131-6126)
- Zakaria Y. Abd Elmageed (ORCID: https://orcid.org/0000-0003-4031-0348)
- Lin Kang (ORCID: https://orcid.org/0000-0002-9186-9574)
- Ramu Anandakrishnan (ORCID: https://orcid.org/0000-0003-0422-3984)
- Pawel Michalak (ORCID: https://orcid.org/0000-0003-4890-8985)
- Robin Varghese (ORCID: https://orcid.org/0000-0001-6244-8220)
- Edward J. Dick (ORCID: https://orcid.org/0000-0003-2373-7921)
Institutions
- Texas Biomedical Research Institute (US)
- Virginia–Maryland College of Veterinary Medicine (US)
- University of Louisiana at Monroe (US)
- Virginia Tech (US)
- Edward Via College of Osteopathic Medicine (US)
- University of Haifa (IL)
Publication Details
- Journal
- Evolution Medicine and Public Health
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1093/emph/eoaf038
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00