Integrating Multi-Omics Summary Data Identifies Candidate Molecular Mechanisms for Major Depression
Our results highlight promising new targets for biomarker and drug target identification and successfully expand on GWAS findings to identify novel associations with MD. However, our study took a broad approach using bulk brain and blood tissues. Future research should expand these analyses into cell- and region-specific contexts.
Authors
- Andrew Mark McIntosh (ORCID: https://orcid.org/0000-0002-0198-4588)
- Xueyi Shen (ORCID: https://orcid.org/0000-0002-0538-4774)
- Naomi R. Wray (ORCID: https://orcid.org/0000-0001-7421-3357)
- Jens Hjerling‐Leffler (ORCID: https://orcid.org/0000-0002-4539-1776)
- Yang Wu (ORCID: https://orcid.org/0000-0002-0128-7280)
- Mark J. Adams (ORCID: https://orcid.org/0000-0002-3599-6018)
- Mary-Ellen Lynall (ORCID: https://orcid.org/0000-0002-1939-7525)
- Laurence Nisbet (ORCID: https://orcid.org/0009-0009-0579-9513)
Institutions
- The University of Queensland (AU)
- Sichuan University (CN)
- Karolinska Institutet (SE)
- University of Oxford (GB)
- West China Hospital of Sichuan University (CN)
- Bridge University (SS)
- University of Edinburgh (GB)
Publication Details
- Journal
- Biological Psychiatry
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.biopsych.2025.11.024
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- UK Research and Innovation
- British Heart Foundation
- European Commission
- National Institutes of Health
- Gillings School of Public Health
- Medical Research Council
- National Health and Medical Research Council