Control your AAV titers with in-line UV-Vis analysis and PAT-driven UF/DF systems

Biomanufacturers face numerous challenges in tangential flow filtration (TFF), including process fragmentation and measurement variability. This poster explores a novel TFF system that leverages real-time, in-line titer measurement through in-line variable pathlength spectroscopy to control the ultrafiltration/diafiltration (UF/DF) process. Case studies outlined in this poster demonstrate improved efficiency and accuracy in AAV titer determination, enhancing process control and reproducibility.