BRAP Promotes the Tumorigenesis of Hepatocellular Carcinoma by Corrupting Cancer Cell Cycle Regulation and Enhancing Immune Evasion
BRAP drives HCC progression by promoting proliferation via RAF/MEK/ERK and shaping an immunosuppressive microenvironment. We identify BRAP as a novel prognostic biomarker and promising immunotherapeutic target in HCC.
Authors
- Shundong Cang (ORCID: https://orcid.org/0000-0002-0146-7724)
- Ruixue Gu (ORCID: https://orcid.org/0009-0007-4469-3047)
- Ling Lan (ORCID: https://orcid.org/0000-0001-9744-4545)
- Qinglin Liu (ORCID: https://orcid.org/0000-0003-4763-2710)
- Lina Liu (ORCID: https://orcid.org/0000-0003-4468-2456)
- Yan Guo (ORCID: https://orcid.org/0009-0009-6881-002X)
- Dongfeng Deng (ORCID: https://orcid.org/0009-0001-0649-1045)
- Qinyu Zhang (ORCID: https://orcid.org/0009-0009-5293-9320)
- Longhao Wang (ORCID: https://orcid.org/0009-0008-9419-2010)
- Fangmiao Gao
Institutions
- Henan Provincial People's Hospital (CN)
- Zhengzhou People's Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Hepatocellular Carcinoma
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/jhc.s547105
- Primary Topic
- Melanoma and MAPK Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00