Precision targeted-immunotherapy for BRAF V600E and MET-amplified biliary tract cancer: two case reports
Combining targeted therapies with immune checkpoint inhibitors showed promising results in 2 patients with advanced BTC driven by specific genetic mutations. Significant tumor reduction and successful surgeries suggest this approach may improve resectability and outcomes. These cases highlight the potential of personalized treatment guided by genetic profiling. Further research is needed to confirm these findings and explore broader applications for this strategy.
Authors
- Xiangyuan Wu (ORCID: https://orcid.org/0000-0002-4090-6857)
- Sidong Xie (ORCID: https://orcid.org/0000-0003-1280-5706)
- Changchang Jia (ORCID: https://orcid.org/0000-0002-5243-0008)
- Tiantian Wang
- Zhanhong Chen (ORCID: https://orcid.org/0000-0003-1802-6375)
- He Xin (ORCID: https://orcid.org/0000-0003-2758-4360)
Institutions
- Sun Yat-sen University (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- The Oncologist
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1093/oncolo/oyaf374
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Guangdong Province