A Digital Health Platform for Remote and Multimodal Monitoring in Neurodegenerative Diseases

Continuous and personalized monitoring are beneficial for patients suffering from neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease and multiple sclerosis. However, such levels of monitoring are seldom ensured by traditional models of care. This paper presents NeuroPredict, a secure edge–cloud Internet of Medical Things (IoMT) platform that addresses this problem by integrating commercial wearables and in-house sensors with cognitive and behavioral evaluations. The NeuroPredict platform links high-frequency physiological signals with periodic cognitive tests through the use of a modular architecture with lightweight device connectivity, a semantic integration layer for timestamp alignment and feature harmonization across heterogeneous streams, and multi-timescale data fusion. Its use of encrypted transport and storage, role-based access control, token-based authentication, identifier separation, and GDPR-aligned governance addresses security and privacy concerns. Moreover, the platform’s user interface was built by considering human-centered design principles and includes role-specific dashboards, alerts, and patient-facing summaries that are meant to encourage engagement and decision-making for patients and healthcare providers. Experimental evaluation demonstrated the NeuroPredict platform’s data acquisition reliability, coherence in multimodal synchronization, and correctness in role-based personalization and reporting. The NeuroPredict platform provides a smart system infrastructure for eHealth and remote monitoring in neurodegenerative care, aligned with priorities on wearables/IoMT integration, data security and privacy, interoperability, and human-centered design.