Triptolide combined with arsenic trioxide induces apoptosis of myelodysplastic syndrome cells by inhibiting the NF-κB signaling pathway
The combined impact of TL and ATO amplifies the expression of p65 within the canonical NF-κB signaling pathway, while inhibiting the expression of IkBα, p52, and RelB in the noncanonical pathway. The combination effect of TL and ATO markedly suppresses the proliferation of MDS cells and induces apoptosis collaboratively, which potentially occurs through a mechanism by inhibiting the NF-κB signaling pathway.
Authors
- Li Sheng (ORCID: https://orcid.org/0009-0002-8257-0324)
- Haiying Hua (ORCID: https://orcid.org/0000-0002-7656-9880)
- Yingying Zhu (ORCID: https://orcid.org/0000-0002-0940-623X)
- Long Ye (ORCID: https://orcid.org/0000-0002-5884-0083)
- Siyu Gu (ORCID: https://orcid.org/0000-0002-3615-2941)
- M. Fang (ORCID: https://orcid.org/0009-0000-7830-896X)
- Zhiyao Wen (ORCID: https://orcid.org/0009-0005-4714-0822)
Institutions
- Jiangnan University (CN)
- Wuxi Fourth People's Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- Medicine
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1097/md.0000000000046206
- Primary Topic
- Natural Compounds in Disease Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00