TMP-SMX-associated acute respiratory distress syndrome with DAIDE pathology in a Korean patient lacking HLA-B*07:02 and C*07:02: A case report
This case represents the first reported TMP-SMX-induced ARDS with diffuse alveolar injury with delayed epithelialization pathology in an East Asian individual, suggesting ethnic variability in HLA-associated risk alleles. The findings underscore the need for population-specific pharmacogenomic investigation in severe drug-induced lung injury.
Authors
- Jun Wan Lee (ORCID: https://orcid.org/0000-0003-4630-597X)
- J.H. Yu (ORCID: https://orcid.org/0000-0002-5579-1925)
- Yong Chae Jung (ORCID: https://orcid.org/0000-0001-7605-2630)
- Yooyoung Chong (ORCID: https://orcid.org/0000-0002-1935-2140)
- Kyung‐Hee Kim (ORCID: https://orcid.org/0000-0003-0214-0296)
Institutions
- Chungnam National University (KR)
- First Candle (US)
- Chungnam National University Hospital (KR)
- S.P.E.C.I.E.S. (US)
Publication Details
- Journal
- Medicine
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1097/md.0000000000046427
- Citations
- 2
- Primary Topic
- Drug-Induced Adverse Reactions
- Type
- article
- Field-Weighted Citation Impact
- 2.79