Perianal Langerhans cell hyperplasia characterized by perianal ulcerative lesions after hemorrhoid surgery: A case report

This case highlights that perianal LCH can masquerade as a nonhealing surgical wound. Its diagnosis requires a high index of suspicion and timely biopsy with immunohistochemical confirmation. Early and accurate diagnosis is crucial for initiating appropriate systemic evaluation and individualized management, which must carefully balance treatment efficacy with patient tolerance to prevent the morbidity associated with progressive multisystem disease.

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Publication Details

Journal
Medicine
Published
2025-12-12
DOI
https://doi.org/10.1097/md.0000000000046381
Primary Topic
Genital Health and Disease
Type
article
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article

Perianal Langerhans cell hyperplasia characterized by perianal ulcerative lesions after hemorrhoid surgery: A case report

Han Yu, Dan Huang, Hua Duan, Jitao Fu et al.
Medicine
Genital Health and Disease
article

Perianal Langerhans cell hyperplasia characterized by perianal ulcerative lesions after hemorrhoid surgery: A case report

Han Yu, Dan Huang, Hua Duan, Jitao Fu, Shubo Gao, Li Zheng, Wenbo Zheng
article en

Abstract

This case highlights that perianal LCH can masquerade as a nonhealing surgical wound. Its diagnosis requires a high index of suspicion and timely biopsy with immunohistochemical confirmation. Early and accurate diagnosis is crucial for initiating appropriate systemic evaluation and individualized management, which must carefully balance treatment efficacy with patient tolerance to prevent the morbidity associated with progressive multisystem disease.

MedicineVol. 104(50)
Affiliated Hospital of Jining Medical University (CN)
Openalex Percentile: Top 40%
Genital Health and Disease
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