The Effect of Opioid-Free Anesthesia with Esketamine on Postoperative Cognitive Dysfunction in Elderly Patients Undergoing Thoracoscopic Surgery: A Prospective, Randomized, Controlled Trial
Esketamine-based OFA did not significantly reduce POCD incidence, and it was associated with improved postoperative reaction time and reduced intraoperative hemodynamic fluctuations.
Authors
- Yongle Zhan (ORCID: https://orcid.org/0000-0002-7378-1915)
- Maohui Luo (ORCID: https://orcid.org/0000-0002-5107-6940)
- Lingfei Wang (ORCID: https://orcid.org/0009-0005-5376-4551)
- Zhaohui Liu (ORCID: https://orcid.org/0000-0001-7246-7548)
- Zeqing Huang (ORCID: https://orcid.org/0000-0003-1034-8118)
- Song Meng (ORCID: https://orcid.org/0009-0008-2846-1921)
Institutions
- Liaoning Cancer Hospital & Institute (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/dddt.s553370
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00