Enhancing mRNA results through strategic RNA design and quality control

“There are several design elements known to improve stability and longevity of mRNA in cells while also reducing innate immunogenicity...”In the last few years, mRNA has moved to the fore in the vaccine and cell and gene therapy fields, and as a result, its successful production for these downstream applications has never been more crucial. In this podcast episode, Róisín McGuigan, Editor, Nucleic Acid Insights, speaks to Ryan Lahr, Senior R&D Scientist, CELLSCRIPT, about design, production, and quality control of synthesized mRNA for translation in cells.

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Publication Details

Journal
Nucleic Acid Insights
Published
2025-03-27
DOI
https://doi.org/10.18609/nuc.2024.007
Primary Topic
RNA Interference and Gene Delivery
Type
article
Field-Weighted Citation Impact
0.00
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article

Enhancing mRNA results through strategic RNA design and quality control

Ryan Lahr
Nucleic Acid Insights
RNA Interference and Gene Delivery
article

Enhancing mRNA results through strategic RNA design and quality control

Ryan Lahr
article en

Abstract

“There are several design elements known to improve stability and longevity of mRNA in cells while also reducing innate immunogenicity...”In the last few years, mRNA has moved to the fore in the vaccine and cell and gene therapy fields, and as a result, its successful production for these downstream applications has never been more crucial. In this podcast episode, Róisín McGuigan, Editor, Nucleic Acid Insights, speaks to Ryan Lahr, Senior R&D Scientist, CELLSCRIPT, about design, production, and quality control of synthesized mRNA for translation in cells.

Nucleic Acid InsightsVol. 2(3)
University of Wisconsin System (US)
Openalex Percentile: Top 63%
RNA Interference and Gene Delivery
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Enhancing mRNA results through strategic RNA design and quality control — Ryan Lahr · Nucleic Acid Insights (2025) | TGRS Research Map | TGRS