Cytotoxic Curvalarol C and Other Compounds from Marine Fungus Asteromyces cruciatus KMM 4696
The present study aimed to isolate new specialized metabolites from the obligate marine fungus <i>Asteromyces cruciatus</i> KMM 4696. The strain KMM 4696 was identified based on the 28S rRNA, ITS, and TEF1 molecular genetic markers. Chromatographic separation of the fungal extract obtained from KI-containing nutrient media cultivation led to the isolation of undescribed pentanorlanostanes curvalarols C (<b>1</b>) and D (<b>2</b>), as well as an undescribed 6/6/5 anthraquinone acruciquinone D (<b>3</b>), along with eight known metabolites. The structures of the isolated compounds were established based on 1D and 2D NMR and MS data. The cytotoxic activity of curvalarol C (<b>1</b>) was assessed in MCF-10A and MCF-7 cells. Curvalarol C exhibited selective activity against cancer MCF-7 cells and inhibiting colony formation with an IC<sub>50</sub> of 4.7 µM.
Authors
- Ekaterina A. Yurchenko (ORCID: https://orcid.org/0000-0001-7737-0980)
- Olesya I. Zhuravleva (ORCID: https://orcid.org/0000-0002-9844-240X)
- K. A. Drozdov (ORCID: https://orcid.org/0000-0001-8600-7761)
- Marina P. Isaeva (ORCID: https://orcid.org/0000-0002-2395-0485)
- Roman S. Popov (ORCID: https://orcid.org/0000-0002-1727-6164)
- Anton N. Yurchenko (ORCID: https://orcid.org/0000-0001-6816-3605)
- G. K. Oleinikova
- Liliana E. Nesterenko (ORCID: https://orcid.org/0009-0002-0698-0698)
- Viktoria E. Chausova (ORCID: https://orcid.org/0000-0003-1601-0345)
- Ekaterina A. Chingizova (ORCID: https://orcid.org/0000-0003-0093-5757)
- Natalya N. Kirichuk
Institutions
- Pacific Institute of Bioorganic Chemistry. GB Elyakova Far Eastern Branch of the Russian Academy of Sciences (RU)
Publication Details
- Journal
- Molecules
- Published
- 2025-12-14
- DOI
- https://doi.org/10.3390/molecules30244772
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Far East Branch, Russian Academy of Sciences