SULF1’s Role in Endothelial Senescence and Atherosclerosis: Insights from Single-Cell and Bulk Transcriptomics
This study highlights the critical role of endothelial senescence in atherosclerosis and identifies <i>SULF1</i> as a key contributor to endothelial senescence and atherogenesis. Targeting <i>SULF1</i> may be a potential therapeutic strategy for mitigating EC senescence and atherosclerosis.
Authors
- Zhiqing He (ORCID: https://orcid.org/0000-0001-8363-1286)
- Chun Liang (ORCID: https://orcid.org/0000-0002-4042-206X)
- Xiangyu Shen
- Zhiren Zhang (ORCID: https://orcid.org/0000-0002-5238-2835)
- Meng-Ting Jiang (ORCID: https://orcid.org/0009-0002-6549-3750)
- Senlin Wan
- Yang-Xi Hu
Institutions
- Army Medical University (CN)
- Chongqing University (CN)
- Daping Hospital (CN)
- Ministry of Education (SA)
- Shanghai Institute of Hematology (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/jir.s544852
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 0.00