Seasonal Genomic Dynamics of Multidrug-Resistant Pathogens in ICU Environments and Perspectives on Phage-Based Interventions
This study reveals distinct seasonal genomic patterns in ICU drug-resistant pathogens and emphasizes the necessity for adaptive infection control strategies. Targeted disinfection, antibiotic stewardship, and consideration of phage therapy as a complementary strategy particularly during winter may help mitigate the spread of high-risk resistant clones, though further in vitro and in vivo validation is required.
Authors
- Shiquan Han (ORCID: https://orcid.org/0009-0005-6564-5787)
- Xiaoyu Li (ORCID: https://orcid.org/0000-0001-8017-207X)
- Yan Zhang (ORCID: https://orcid.org/0000-0001-8814-4727)
- Xinyue Ma (ORCID: https://orcid.org/0009-0009-4582-2175)
- Fengli Wang (ORCID: https://orcid.org/0009-0001-6506-3315)
Institutions
- Dalian University of Technology (CN)
- Dalian University (CN)
- Dalian Municipal Central Hospital (CN)
Publication Details
- Journal
- Infection and Drug Resistance
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/idr.s549220
- Primary Topic
- Bacteriophages and microbial interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00