Producing low-immunogenicity, high-stability mRNA with dsRNA reduction to <0.005% (LLOQ)

Optimizing mRNA design for therapeutic applications is critical to ensure maximum protein expression, low impurities and a reduced immune response. This 14-minute video presentation, accompanied by a poster summary, describes how to efficiently generate lower immunogenicity mRNA for downstream applications while also reducing dsRNA using the INCOGNITO™ mScript™ Complete mRNA Production Systems. NEW INTERACTIVE FORMAT Listen to our expert speaker. Watch the video. Read the summary. Focus in on the data. Download the PDF. It has never been easier to quickly access the information you want. All in one place—at the click of a button.

Authors

Publication Details

Journal
Nucleic Acid Insights
Published
2025-05-21
DOI
https://doi.org/10.18609/nuc.2025.016
Primary Topic
RNA Interference and Gene Delivery
Type
article
Field-Weighted Citation Impact
0.00
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article

Producing low-immunogenicity, high-stability mRNA with dsRNA reduction to <0.005% (LLOQ)

Jen Dennin
Nucleic Acid Insights
RNA Interference and Gene Delivery
article

Producing low-immunogenicity, high-stability mRNA with dsRNA reduction to <0.005% (LLOQ)

Jen Dennin
article en

Abstract

Optimizing mRNA design for therapeutic applications is critical to ensure maximum protein expression, low impurities and a reduced immune response. This 14-minute video presentation, accompanied by a poster summary, describes how to efficiently generate lower immunogenicity mRNA for downstream applications while also reducing dsRNA using the INCOGNITO™ mScript™ Complete mRNA Production Systems. NEW INTERACTIVE FORMAT Listen to our expert speaker. Watch the video. Read the summary. Focus in on the data. Download the PDF. It has never been easier to quickly access the information you want. All in one place—at the click of a button.

Nucleic Acid InsightsVol. 2(4)
Openalex Percentile: Top 63%
RNA Interference and Gene Delivery
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Producing low-immunogenicity, high-stability mRNA with dsRNA reduction to &lt;0.005% (LLOQ) — Jen Dennin · Nucleic Acid Insights (2025) | TGRS Research Map | TGRS