Fibroblast pentose phosphate pathway activation upon decreased circPLCE1 exacerbates intestinal fibrosis in Crohn’s disease
Our findings delineate a circPLCE1/XYLB/Xu5P axis in fibroblasts which orchestrates PPP and fibrogenesis, unveiling a novel therapeutic target for intestinal fibrosis of CD.
Authors
- Ren Mao (ORCID: https://orcid.org/0000-0002-5523-8185)
- Rongchang Li (ORCID: https://orcid.org/0009-0003-3778-6959)
- Florian Rieder (ORCID: https://orcid.org/0000-0002-9087-1568)
- Pingxin Zhang
- Feng Zhi-yin
- Sinan Lin (ORCID: https://orcid.org/0000-0002-0977-9036)
- Longyuan Zhou (ORCID: https://orcid.org/0000-0002-3057-2566)
- Changhao Chen (ORCID: https://orcid.org/0000-0002-9924-9054)
- Minhu Chen (ORCID: https://orcid.org/0000-0003-2421-9966)
- Yao Zhang (ORCID: https://orcid.org/0000-0001-5858-6225)
- Jing Nie (ORCID: https://orcid.org/0000-0001-5080-6553)
Institutions
- Cleveland Clinic (US)
- Sun Yat-sen University (CN)
- Shanghai Jiao Tong University (CN)
- Ruijin Hospital (CN)
- Wuhan University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Zhongnan Hospital of Wuhan University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Gut
- Published
- 2025-12-13
- DOI
- https://doi.org/10.1136/gutjnl-2025-336415
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00