Molecular epidemiological characteristics, antifungal resistance and pathogenicity of Candidozyma auris in Guangzhou, South China

In this study, we identified two major clades of C. auris prevalent in the Guangzhou area and compared their epidemiological characteristics, drug resistance profiles, and virulence factors. These include mutations in drug-resistant genes, hydrolase activity, biofilm formation ability, and pathogenicity in the Galleria mellonella infection model. Understanding the biological characteristics of C. auris, as well as studying its drug resistance mechanisms and virulence, is crucial for advancing our knowledge in this field. Our study contributes to the expansion of the genetic database of C. auris and provides a scientific foundation for enhancing infection control strategies and antifungal stewardship in South China.